Mecp2^tm1Jchr
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm1Jchr
• Name: methyl CpG binding protein 2; targeted mutation 1, John Christodoulou
• MGI ID: MGI:3583768
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm1Jchr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99561
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette replaced the coding sequence for the methyl-binding domain. RT-PCR of mutants confirmed no transcript was present for this coding region. (J:99561)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 41 strains or lines available

References

• Original: J:99561 Weaving LS, et al., Mutations of CDKL5 cause a severe neurodevelopmental disorder with infantile spasms and mental retardation. Am J Hum Genet. 2004 Dec;75(6):1079-93
• All: 1 reference(s)