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F11rGt(KST235)Byg
Gene trapped Allele Detail
Summary
Symbol: F11rGt(KST235)Byg
Name: F11 receptor; gene trap KST235, BayGenomics
MGI ID: MGI:3583782
Synonyms: F11rGt(pGT1pfs)1Upn, JAM-A-, Jam-Agt
Gene: F11r  Location: Chr1:171265129-171292161 bp, + strand  Genetic Position: Chr1, 79.43 cM, cytoband H2
Alliance: F11rGt(KST235)Byg page
Mutation
origin
Mutant Cell Line:  KST235
Germline Transmission:  Earliest citation of germline transmission: J:127992
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1TMpf
 
Mutation detailsA gene trap vector (pGT1TMpfs) insertion resulted in the fusion of the first Ig domain to TMbetageo, an artificial protein created from the transmembrane domain of rat Cd4 joined to the catalytically active domains of betagalactosidase and neomycin genes followed by an IRES and placental alkaline phosphatase reporter cassette. The betagalactosidase and neomycin genes are flanked by Frt sites. The absence of protein product in the endothelium of the aorta was confirmed by immunohistochemistry. (J:99570)
Sequence Tags: 
Sequence tag details (1 tag)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 9 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F11r Mutation:  31 strains or lines available
References
Original:  J:99570 Parris JJ, et al., JAM-A expression during embryonic development. Dev Dyn. 2005 Aug;233(4):1517-24
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory