Zfpm1^tm4Sho
Targeted Allele Detail

Summary

• Symbol: Zfpm1^tm4Sho
• Name: zinc finger protein, multitype 1; targeted mutation 4, Stuart Orkin
• MGI ID: MGI:3583784
• Synonyms: FOG-1^fl
• Gene: Zfpm1 Location: Chr8:123008880-123063990 bp, + strand Genetic Position: Chr8, 70.86 cM, cytoband E1
• Alliance: Zfpm1^tm4Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99745
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the intron preceding zinc finger 1, and a loxP flanked neomycin resistance cassette was inserted approximately 500 base pairs 3' of the terminal exon. The neomycin resistance cassette was removed by Cre-mediated recombination in the final allele, leaving loxP sites flanking most of the coding region. (J:99745)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfpm1 Mutation: 33 strains or lines available

References

• Original: J:99745 Katz SG, et al., Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14030-5
• All: 3 reference(s)