Cldn19^tm1Sts
Targeted Allele Detail

Summary

• Symbol: Cldn19^tm1Sts
• Name: claudin 19; targeted mutation 1, Shoichiro Tsukita
• MGI ID: MGI:3583804
• Synonyms: Cldn19^-
• Gene: Cldn19 Location: Chr4:119112638-119119635 bp, + strand Genetic Position: Chr4, 55.34 cM
• Alliance: Cldn19^tm1Sts page

Absence of tight junctions in peripheral myelinated axons of Cldn19^tm1Sts/Cldn19^tm1Sts mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99659
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace all 4 exons with a neomycin resistance gene. RT-PCR confirmed absence of transcript in mutant kidney samples. (J:99659)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn19 Mutation: 16 strains or lines available

References

• Original: J:99659 Miyamoto T, et al., Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. J Cell Biol. 2005 May 9;169(3):527-38
• All: 1 reference(s)