Hmga1^tm1Brun
Targeted Allele Detail

Summary

• Symbol: Hmga1^tm1Brun
• Name: high mobility group AT-hook 1; targeted mutation 1, Antonio Brunetti
• MGI ID: MGI:3583805
• Synonyms: Hmga1^-
• Gene: Hmga1 Location: Chr17:27775471-27782648 bp, + strand Genetic Position: Chr17, 14.5 cM
• Alliance: Hmga1^tm1Brun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99652
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3, which contains the start site, and exons 4 and 5, were replaced with a neomycin resistance gene. RT-PCR failed to detect transcript from mutant muscle and fat samples. (J:99652)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmga1 Mutation: 23 strains or lines available

References

• Original: J:99652 Foti D, et al., Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. Nat Med. 2005 Jul;11(7):765-73
• All: 7 reference(s)