Tg(Upk2-cre)6Xrw
Transgene Detail

Summary

• Symbol: Tg(Upk2-cre)6Xrw
• Name: transgene insertion 6, Xue-Ru Wu
• MGI ID: MGI:3583893
• Synonyms: Tg(Upk1b-cre)6Xrw, UPII-Cre
• Transgene: Tg(Upk2-cre)6Xrw Location: unknown
• Alliance: Tg(Upk2-cre)6Xrw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Upk2-cre)6Xrw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Upk2 (MGI:98913)

• Mutation details: A construct was generated having a 3.6 kb fragment of the mouse Upk2 promoter, cre recombinase and a polyA signal. The transgene was purified and microinjected into fertilized FVB/N oocytes. Three founder lines 4,5,6) were obtained, all showing germline transmission and urothelium-specific cre mRNA expression (not detected in any other tissues). Mice established from founder 6 were crossed to reporter mice to verify cre recombinase activity in the urothelium. (J:99613)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Upk2 (mouse) Summary of all recombinase alleles driven by Upk2. Comparative matrix view of recombinase activities Alliance mouse Upk2 gene page

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Upk2-cre)6Xrw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:99613 Mo L, et al., Gene deletion in urothelium by specific expression of Cre recombinase. Am J Physiol Renal Physiol. 2005 Sep;289(3):F562-8
• All: 15 reference(s)