Ipmk^tm1Yrk
Targeted Allele Detail

Summary

• Symbol: Ipmk^tm1Yrk
• Name: inositol polyphosphate multikinase; targeted mutation 1, John D York
• MGI ID: MGI:3583918
• Gene: Ipmk Location: Chr10:71183574-71221715 bp, + strand Genetic Position: Chr10, 36.89 cM, cytoband B5.2
• Alliance: Ipmk^tm1Yrk page

Morphological analysis of Ipmk^tm1Yrk/Ipmk^tm1Yrk embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99723
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4, encoding the critical kinase motif DVKIG and residues critical to protein folding, was replaced with a neomycin resistance cassette via homologous recombination. In situ hybridization experiments indicated that no detectable transcript was expressed from this allele. (J:99723)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ipmk Mutation: 30 strains or lines available

References

• Original: J:99723 Frederick JP, et al., An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8454-9
• All: 2 reference(s)