Myc^tm1Lbox
Targeted Allele Detail

Summary

• Symbol: Myc^tm1Lbox
• Name: myelocytomatosis oncogene; targeted mutation 1, Linda M Boxer
• MGI ID: MGI:3583919
• Synonyms: IgH-3'E-myc
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm1Lbox page

Histopathological analysis of lymphomas in Myc^tm1Lbox/Myc^tm1Lbox and Myc^tm1Lbox/Myc⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97900
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Insertion
• Mutation details: The IgH 3' enhancers SH1234 were inserted upstream of the locus. RT-PCR of mutants demonstrated elevated transcript levels in spleenic B-lymphocytes, but normal levels in brain, liver, kidney, lung and thymus. (J:97900)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 43 strains or lines available

References

• Original: J:97900 Wang J, et al., Regulatory elements in the immunoglobulin heavy chain gene 3'-enhancers induce c-myc deregulation and lymphomagenesis in murine B cells. J Biol Chem. 2005 Apr 1;280(13):12766-73
• All: 2 reference(s)