Polg^tm1Prol
Targeted Allele Detail

Summary

• Symbol: Polg^tm1Prol
• Name: polymerase (DNA directed), gamma; targeted mutation 1, Tomas A Prolla
• MGI ID: MGI:3583920
• Synonyms: mtDNA-mutator, Polg^A, PolgA^D257A, Polg^m, Polg^mut, Polg^tm1Tprol
• Gene: Polg Location: Chr7:79095979-79116110 bp, - strand Genetic Position: Chr7, 45.04 cM, cytoband E
• Alliance: Polg^tm1Prol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99764
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting construct was designed to introduce an AC to CT two-base substitution in positions 1054 and 1055, resulting in a critical residue substitution in the conserved exonuclease domain (D257A). (J:99764)

Disease models

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Polg Mutation: 58 strains or lines available

References

• Original: J:99764 Kujoth GC, et al., Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005 Jul 15;309(5733):481-4
• All: 45 reference(s)