Cadps^tm1Bros
Targeted Allele Detail

Summary

• Symbol: Cadps^tm1Bros
• Name: Ca2+-dependent secretion activator; targeted mutation 1, Nils Brose
• MGI ID: MGI:3583931
• Gene: Cadps Location: Chr14:9646684-10097200 bp, + strand Genetic Position: Chr14, 6.37 cM, cytoband A2
• Alliance: Cadps^tm1Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99762
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the 3' exon containing bp 1259-1380, encoding amino acids 399-439. Western blot failed to detect protein in mutant brain and adrenal samples. (J:99762)

Expression

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cadps Mutation: 70 strains or lines available

References

• Original: J:99762 Speidel D, et al., CAPS1 regulates catecholamine loading of large dense-core vesicles. Neuron. 2005 Apr 7;46(1):75-88
• All: 16 reference(s)