Cspg5^tm1Fgr
Targeted Allele Detail

Summary

• Symbol: Cspg5^tm1Fgr
• Name: chondroitin sulfate proteoglycan 5; targeted mutation 1, Fritz G Rathjen
• MGI ID: MGI:3583953
• Synonyms: CALEB^-
• Gene: Cspg5 Location: Chr9:110072851-110091644 bp, + strand Genetic Position: Chr9, 59.89 cM
• Alliance: Cspg5^tm1Fgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99761
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 1 and 2, which encompass the start codon and N-terminal half of the EGF domain. Western blot confirmed absence of protein in mutant brains. (J:99761)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cspg5 Mutation: 43 strains or lines available

References

• Original: J:99761 Juttner R, et al., Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. Neuron. 2005 Apr 21;46(2):233-45
• All: 3 reference(s)