Ctsl^tm1Alpk
Targeted Allele Detail

Summary

• Symbol: Ctsl^tm1Alpk
• Name: cathepsin L; targeted mutation 1, AstraZeneca UK Ltd
• MGI ID: MGI:3583996
• Gene: Ctsl Location: Chr13:64509704-64518586 bp, - strand Genetic Position: Chr13, 33.26 cM
• Alliance: Ctsl^tm1Alpk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99755
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 4 in reverse orientation to transcription. Northern blot of liver and brain tissue demonstrated the complete absence of protein in mutants. (J:99755)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsl Mutation: 32 strains or lines available

References

• Original: J:99755 Potts W, et al., Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy. Int J Exp Pathol. 2004 Apr;85(2):85-96
• All: 3 reference(s)