Tg(Col2a1-PTHR1*H223R)BHju
Transgene Detail

Summary

• Symbol: Tg(Col2a1-PTHR1*H223R)BHju
• Name: transgene insertion B, Harald Juppner
• MGI ID: MGI:3584015
• Synonyms: Tg-B
• Transgene: Tg(Col2a1-PTHR1*H223R)BHju Location: unknown
• Alliance: Tg(Col2a1-PTHR1*H223R)BHju page

Skeletal images of wild-type and Tg(Col2a1-PTHR1*H223R)BHju/Tg(Col2a1-PTHR1*H223R)BHju mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Constitutively active, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Col2a1-PTHR1*H223R)BHju expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTHLH (5744)

  Pthlh

  (MGI:97800)

• Mutation details: A 1,880-bp cDNA fragment encoding the constitutively active human PTHR1 containing an H223R mutation (HKrk-H223R) was placed downstream of the rat alpha (II) collagen promoter. The B line contains several concatemeric copies of the transgene with two closely linked integration sites. (J:77639)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:77639 Schipani E, et al., Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13689-94
• All: 3 reference(s)