Lmo2^tm3Thr
Targeted Allele Detail

Summary

• Symbol: Lmo2^tm3Thr
• Name: LIM domain only 2; targeted mutation 3, Terence H Rabbitts
• MGI ID: MGI:3584019
• Synonyms: Lmo2^fl
• Gene: Lmo2 Location: Chr2:103788331-103812223 bp, + strand Genetic Position: Chr2, 54.46 cM
• Alliance: Lmo2^tm3Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86869
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A set of two targeting vectors were used to insert a loxP-hygro into intron 4 and a puro-loxP into intron 6, to flank the majority of the coding sequence. (J:86869)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmo2 Mutation: 31 strains or lines available

References

• Original: J:86869 McCormack MP, et al., The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development. Mol Cell Biol. 2003 Dec;23(24):9003-13
• All: 1 reference(s)