Rrn3^tm1.1Igt
Targeted Allele Detail

Summary

• Symbol: Rrn3^tm1.1Igt
• Name: RRN3 RNA polymerase I transcription factor homolog (yeast); targeted mutation 1.1, Ingrid Grummt
• MGI ID: MGI:3584035
• Synonyms: TIF-1A^fl
• Gene: Rrn3 Location: Chr16:13598572-13632703 bp, + strand Genetic Position: Chr16, 9.59 cM
• Alliance: Rrn3^tm1.1Igt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99711
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRP-flanked neomycin resistance cassette downstream of a loxP site was inserted into intron 11 and a second loxP site was inserted in to intron 14 via homologous recombination. Heterozygous mice were bred with Tg(ACTFLPe)9205Dym carriers to excise the neomycin resistance cassette, leaving the loxP sites in introns 11 and 14. (J:99711)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rrn3 Mutation: 42 strains or lines available

References

• Original: J:99711 Yuan X, et al., Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell. 2005 Jul 1;19(1):77-87
• All: 11 reference(s)