Chga^tm1Skmt
Targeted Allele Detail

Summary

• Symbol: Chga^tm1Skmt
• Name: chromogranin A; targeted mutation 1, Sushil K Mahata
• MGI ID: MGI:3584125
• Synonyms: Chga^-, Chga KO
• Gene: Chga Location: Chr12:102521228-102531287 bp, + strand Genetic Position: Chr12, 51.66 cM
• Alliance: Chga^tm1Skmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99805
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated excision was used to remove all of exon 1 and 1.5 kb of proximal promoter sequence. Quantitative RT-PCR failed to detect transcript in endocrine or neuroendocrine tissues of mutants. (J:99805)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chga Mutation: 33 strains or lines available

References

• Original: J:99805 Mahapatra NR, et al., Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest. 2005 Jul;115(7):1942-52
• All: 19 reference(s)