Spry2^tm1Ayos
Targeted Allele Detail

Summary

• Symbol: Spry2^tm1Ayos
• Name: sprouty RTK signaling antagonist 2; targeted mutation 1, Akihiko Yoshimura
• MGI ID: MGI:3584128
• Synonyms: Sprouty2^-
• Gene: Spry2 Location: Chr14:106129381-106134253 bp, - strand Genetic Position: Chr14, 56.16 cM
• Alliance: Spry2^tm1Ayos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99827
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced most of exon 2. RT-PCR failed to detect transcript and protein was absent in Western blot of mutant MEFs. (J:99827)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spry2 Mutation: 24 strains or lines available

References

• Original: J:99827 Taketomi T, et al., Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nat Neurosci. 2005 Jul;8(7):855-7
• All: 5 reference(s)