Ccne1^tm1Jro
Targeted Allele Detail

Summary

• Symbol: Ccne1^tm1Jro
• Name: cyclin E1; targeted mutation 1, James M Roberts
• MGI ID: MGI:3584133
• Synonyms: E^T393A
• Gene: Ccne1 Location: Chr7:37797409-37806915 bp, - strand Genetic Position: Chr7, 25.35 cM
• Alliance: Ccne1^tm1Jro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99695
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: A floxed neomycin resistance cassette was inserted into intron 10 and sequence in exon 11 encoding amino-acid residue 393 was mutated from Thr to Ala (ACA to GCA) preventing phosphorylation of this residue. Heterozygotes were crossed with carriers of Meox2^tm1(cre)Sor, excising the neomycin resistance cassette and leaving the T393A point mutation. (J:99695)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccne1 Mutation: 23 strains or lines available

References

• Original: J:99695 Loeb KR, et al., A mouse model for cyclin E-dependent genetic instability and tumorigenesis. Cancer Cell. 2005 Jul;8(1):35-47
• All: 2 reference(s)