Hipk1^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Hipk1^tm1Mak
• Name: homeodomain interacting protein kinase 1; targeted mutation 1, Tak Wah Mak
• MGI ID: MGI:3584135
• Synonyms: HIPK1^-
• Gene: Hipk1 Location: Chr3:103647131-103698879 bp, - strand Genetic Position: Chr3, 45.52 cM, cytoband F3
• Alliance: Hipk1^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99823
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace 2.7 kb of genomic DNA containing exon 1, encoding the putative kinase domain, with a neomycin resistance gene. Northern blot of mutant MEFs confirmed successful targeting. (J:99823)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hipk1 Mutation: 61 strains or lines available

References

• Original: J:99823 Kondo S, et al., Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5431-6
• All: 3 reference(s)