Adam22^tm1Sag
Targeted Allele Detail

Summary

• Symbol: Adam22^tm1Sag
• Name: a disintegrin and metallopeptidase domain 22; targeted mutation 1, Koji Sagane
• MGI ID: MGI:3584137
• Gene: Adam22 Location: Chr5:8122352-8418160 bp, - strand Genetic Position: Chr5, 3.39 cM
• Alliance: Adam22^tm1Sag page

Uncoordinated movements in Adam22^tm1Sag/Adam22^tm1Sag mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99692
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A termination codon and neomycin resistance cassette were inserted into exon 8 in the pro-protein domain. Western blot using antisera to the cytoplasmic domain failed to detect mature protein. (J:99692)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adam22 Mutation: 72 strains or lines available

References

• Original: J:99692 Sagane K, et al., Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice. BMC Neurosci. 2005 May 6;6(1):33
• All: 5 reference(s)