Gria2^tm1Rlh
Targeted Allele Detail

Summary

• Symbol: Gria2^tm1Rlh
• Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 1, Richard L Huganir
• MGI ID: MGI:3584143
• Synonyms: GluR2delta7
• Gene: Gria2 Location: Chr3:80588757-80710142 bp, - strand Genetic Position: Chr3, 35.5 cM
• Alliance: Gria2^tm1Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99813
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An artificial stop codon was inserted upstream of the exon encoding transmembrane 4 and the C terminus region. A floxed neo included in the construct was deleted via cre-mediated recombination. Western blot failed to detect protein using the antibody designed to recognize the last 7 amino acids of the C terminus. (J:99813)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria2 Mutation: 79 strains or lines available

References

• Original: J:99813 Gardner SM, et al., Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF. Neuron. 2005 Mar 24;45(6):903-15
• All: 9 reference(s)