Gria3^tm2Rlh
Targeted Allele Detail

Summary

• Symbol: Gria3^tm2Rlh
• Name: glutamate receptor, ionotropic, AMPA3 (alpha 3); targeted mutation 2, Richard L Huganir
• MGI ID: MGI:3584157
• Synonyms: Glur3^-
• Gene: Gria3 Location: ChrX:40489731-40767478 bp, + strand Genetic Position: ChrX, 23.19 cM
• Alliance: Gria3^tm2Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99813
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a neomycin resistance cassette in the exon encoding transmembranes 1 and 2. Western blot of mutant brain samples confirmed absence of protein. (J:99813)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria3 Mutation: 12 strains or lines available

References

• Original: J:99813 Gardner SM, et al., Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF. Neuron. 2005 Mar 24;45(6):903-15
• All: 2 reference(s)