Pak3^tm1Zpj
Targeted Allele Detail

Summary

• Symbol: Pak3^tm1Zpj
• Name: p21 (RAC1) activated kinase 3; targeted mutation 1, Zhengping Jia
• MGI ID: MGI:3584167
• Synonyms: PAK3^-
• Gene: Pak3 Location: ChrX:142301587-142580792 bp, + strand Genetic Position: ChrX, 64.5 cM
• Alliance: Pak3^tm1Zpj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99811
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a pgk-neo cassette was designed to eliminate the region encoding the entire kinase domain. Protein was undetected in Western blot analyses of mutant brain lysates. (J:99811)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pak3 Mutation: 26 strains or lines available

References

• Original: J:99811 Meng J, et al., Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J Neurosci. 2005 Jul 13;25(28):6641-50
• All: 4 reference(s)