Man2b1^tm1Psa
Targeted Allele Detail

Summary

• Symbol: Man2b1^tm1Psa
• Name: mannosidase 2, alpha B1; targeted mutation 1, Paul Saftig
• MGI ID: MGI:3584185
• Synonyms: alpha-Man-
• Gene: Man2b1 Location: Chr8:85809941-85824215 bp, + strand Genetic Position: Chr8, 41.55 cM, cytoband C2
• Alliance: Man2b1^tm1Psa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56659
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 2, resulting in a premature stop codon in the ORF. The complete absence of transcript in mutants was confirmed by Northern blot and RT-PCR analyses. (J:56659)

Disease models

Expression

In Structures Affected by this Mutation:

24 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Man2b1 Mutation: 46 strains or lines available

References

• Original: J:56659 Stinchi S, et al., Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling a mild form of human alpha-mannosidosis. Hum Mol Genet. 1999 Aug;8(8):1365-72
• All: 4 reference(s)