Npb^tm1Ywa
Targeted Allele Detail

Summary

• Symbol: Npb^tm1Ywa
• Name: neuropeptide B; targeted mutation 1, Masashi Yanagisawa
• MGI ID: MGI:3584339
• Synonyms: NPB^-
• Gene: Npb Location: Chr11:120499303-120499919 bp, + strand Genetic Position: Chr11, 84.33 cM
• Alliance: Npb^tm1Ywa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99861
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the entire coding region and the single intron with a neomycin resistance gene. In situ hybridization demonstrated the complete lack of mRNA expression. (J:99861)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npb Mutation: 8 strains or lines available

References

• Original: J:99861 Kelly MA, et al., Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain. Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9942-7
• All: 1 reference(s)