7630403G23Rik^{Tg(Th-cre)1Tmd}
Transgenic Allele Detail

Summary

• Symbol: 7630403G23Rik^{Tg(Th-cre)1Tmd}
• Name: RIKEN cDNA 7630403G23 gene; transgene insertion 1, Ted M Dawson
• MGI ID: MGI:3584380
• Synonyms: Tg(Th-cre)1Tmd, TH-cre
• Gene: 7630403G23Rik Location: Chr9:33953667-33970315 bp, + strand Genetic Position: Chr9, Syntenic
• Alliance: 7630403G23Rik^{Tg(Th-cre)1Tmd} page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutations: Insertion, Intragenic deletion
• 7630403G23Rik^{Tg(Th-cre)1Tmd} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Th (25085)

  Th	(MGI:98735)

• Mutation details: Cre recombinase is expressed under the control of the rat tyrosine hydroxylase promoter. Cre recombinase activity is detected in catecholaminergic cells. This is a representative record representing TH-cre1 - TH-cre5 all of which have identical activity. Line 1 inserted into the gene at 33514690-34139124 (Build GRCm38/mm10) resulting in a 624,434 bp deletion. Founder line 1 has a copy number of greater than 20. (J:99848)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Th (rat) Summary of all recombinase alleles driven by Th. Comparative matrix view of recombinase activities Alliance rat Th gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any 7630403G23Rik Mutation: 3 strains or lines available

References

• Original: J:99848 Savitt JM, et al., Bcl-x is required for proper development of the mouse substantia nigra. J Neurosci. 2005 Jul 20;25(29):6721-8
• All: 103 reference(s)