Polg^tm1.2Lrsn
Targeted Allele Detail

Summary

• Symbol: Polg^tm1.2Lrsn
• Name: polymerase (DNA directed), gamma; targeted mutation 1.2, Nils-Goran Larsson
• MGI ID: MGI:3584444
• Synonyms: PolgA^-
• Gene: Polg Location: Chr7:79095979-79116110 bp, - strand Genetic Position: Chr7, 45.04 cM, cytoband E
• Alliance: Polg^tm1.2Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99794
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice carrying the floxed allele Polg^tm1Lrsn were crossed with mice expressing cre ubiquitously, causing the removal of exon 3. Deletion of exon 3 results in a frameshift mutation leading to a stop codon early in exon 4 and the loss of nearly all active domains of the locus. (J:99794)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Polg Mutation: 58 strains or lines available

References

• Original: J:99794 Hance N, et al., Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis. Hum Mol Genet. 2005 Jul 1;14(13):1775-83
• All: 2 reference(s)