Rr99^tm1Litt
Targeted Allele Detail

Summary

• Symbol: Rr99^tm1Litt
• Name: regulatory region 99; targeted mutation 1, Dan R Littman
• MGI ID: MGI:3584476
• Synonyms: Cd8a^tm1Litt, E8i N
• Gene: Rr99 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr99^tm1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50624
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two DNase I hypersensitive sites which together constitute Cd8a E8i enhancer element were replaced with a floxed neomycin resistance cassette. (J:50624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr99 Mutation: 0 strains or lines available

References

• Original: J:50624 Ellmeier W, et al., Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity. 1998 Oct;9(4):485-96
• All: 5 reference(s)