Cd8a^tm1.1Litt
Targeted Allele Detail

Summary

• Symbol: Cd8a^tm1.1Litt
• Name: CD8 subunit alpha; targeted mutation 1.1, Dan R Littman
• MGI ID: MGI:3584478
• Synonyms: E8i delta
• Gene: Cd8a Location: Chr6:71350411-71356155 bp, + strand Genetic Position: Chr6, 32.14 cM, cytoband C
• Alliance: Cd8a^tm1.1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50624
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was derived from Cd8a^tm1Litt by crossing to mice expressing an unspecified CMV-cre transgene which results in germline excision of the floxed neomycin cassette. (J:50624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd8a Mutation: 39 strains or lines available

References

• Original: J:50624 Ellmeier W, et al., Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity. 1998 Oct;9(4):485-96
• All: 7 reference(s)