Ppif^tm1Maf
Targeted Allele Detail

Summary

• Symbol: Ppif^tm1Maf
• Name: peptidylprolyl isomerase F (cyclophilin F); targeted mutation 1, Michael A Forte
• MGI ID: MGI:3586298
• Synonyms: CyPD-KO, Ppif^-
• Gene: Ppif Location: Chr14:25694578-25700892 bp, + strand Genetic Position: Chr14, 15.06 cM
• Alliance: Ppif^tm1Maf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99922
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin resistance cassette resulted in the deletion of the first three exons of the locus, including 20 bp upstream of the ATG. No protein was detected in mutant liver, kidney or heart samples. (J:99922)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppif Mutation: 20 strains or lines available

References

• Original: J:99922 Basso E, et al., Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. J Biol Chem. 2005 May 13;280(19):18558-61
• All: 30 reference(s)