Csf2^tm1Dran
Targeted Allele Detail

Summary

• Symbol: Csf2^tm1Dran
• Name: colony stimulating factor 2 (granulocyte-macrophage); targeted mutation 1, Glen Dranoff
• MGI ID: MGI:3586299
• Synonyms: GM-CSF ^-
• Gene: Csf2 Location: Chr11:54138097-54140493 bp, - strand Genetic Position: Chr11, 32.13 cM
• Alliance: Csf2^tm1Dran page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67404
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin resistance cassette replaced exons 3 and 4 in an ES cell line in which the Il3 gene had already been targeted (MGI:2446538). Absence of protein was demonstrated immunologically. (J:67404)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Csf2^tm1Dran

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csf2 Mutation: 35 strains or lines available

References

• Original: J:67404 Gillessen S, et al., Overlapping roles for granulocyte-macrophage colony-stimulating factor and interleukin-3 in eosinophil homeostasis and contact hypersensitivity. Blood. 2001 Feb 15;97(4):922-8
• All: 9 reference(s)