Il3^tm1Tyb
Targeted Allele Detail

Summary

• Symbol: Il3^tm1Tyb
• Name: interleukin 3; targeted mutation 1, Victor L J Tybulewicz
• MGI ID: MGI:3586300
• Synonyms: Il3^tm1Mur
• Gene: Il3 Location: Chr11:54156129-54158103 bp, - strand Genetic Position: Chr11, 32.13 cM, cytoband B1
• Alliance: Il3^tm1Tyb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35829
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: As a result of a frameshift mutation in exon 1 and the deletion of exon 2, this allele lacks functional protein. (J:35829)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il3 Mutation: 31 strains or lines available

References

• Original: J:35829 Nishinakamura R, et al., Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions. Blood. 1996 Oct 1;88(7):2458-64
• All: 8 reference(s)