Fxyd2^tm1Kdr
Targeted Allele Detail

Summary

• Symbol: Fxyd2^tm1Kdr
• Name: FXYD domain-containing ion transport regulator 2; targeted mutation 1, Gerald M Kidder
• MGI ID: MGI:3586329
• Synonyms: Fxyd2^-
• Gene: Fxyd2 Location: Chr9:45311007-45321576 bp, + strand Genetic Position: Chr9, 24.84 cM, cytoband B
• Alliance: Fxyd2^tm1Kdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99929
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 4, encoding most of the transmembrane domain, was replaced with a neomycin resistance gene and a lacZ gene. Absense of gamma subunits in mutants was confirmed by Western blot. (J:99929)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fxyd2 Mutation: 13 strains or lines available

References

• Original: J:99929 Jones DH, et al., Na,K-ATPase from mice lacking the gamma subunit (FXYD2) exhibits altered Na+ affinity and decreased thermal stability. J Biol Chem. 2005 May 13;280(19):19003-11
• All: 4 reference(s)