Tg(Gata1-Zfpm1)1Sho
Transgene Detail

Summary

• Symbol: Tg(Gata1-Zfpm1)1Sho
• Name: transgene insertion 1, Stuart Orkin
• MGI ID: MGI:3586378
• Transgene: Tg(Gata1-Zfpm1)1Sho Location: unknown
• Alliance: Tg(Gata1-Zfpm1)1Sho page

Cardiac defects in Zfpm1^tm1Sho/Zfpm1^tm1Sho Tg(Gata1-Zfpm1)1Sho mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Gata1-Zfpm1)1Sho expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Zfpm1 (MGI:1095400)

• Mutation details: The transgene consists of a 3 kb murine Zfpm1 cDNA under the control of the Gata-1 promoter. A rabbit globin poly(A) addition region and simian virus 40 sequence for polyadenylation signals and transgene detection were also added to the construct. Gata-1 drives the expression of Zfpm1 in the hematopoietic compartment. (J:99745)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:99745 Katz SG, et al., Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14030-5
• All: 2 reference(s)