H2-Ab1^bm12
Spontaneous Allele Detail

Summary

• Symbol: H2-Ab1^bm12
• Name: histocompatibility 2, class II antigen A, beta 1; b haplotype mutation 12
• MGI ID: MGI:3586447
• Synonyms: bm12, H-2^bm, H2^bm12
• Gene: H2-Ab1 Location: Chr17:34482201-34488392 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Ab1^bm12 page

Mutation origin

• Strain of Origin: (C57BL/6 x BALB/c)F1

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: Three non-consecutive nucleotide changes occurred, resulting in three amino acid substitutions in the beta1 exon. The amino acid changes consist of codon 67 (isoleucine to phenylalanine), codon 70 (arginine to glutamine) and codon 71 (threonine to lysine). These changes were likely the product of gene conversion of H2-Ab1^b with sequence from H2-Eb^b. (J:99766, J:99767, J:100015, J:109266)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any H2-Ab1 Mutation: 83 strains or lines available

Notes

Genbank ID for this allele: M54876

References

• Original: J:99770 McKenzie IF, et al., B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse. J Exp Med. 1979 Dec 1;150(6):1323-38
• All: 155 reference(s)