Park7^tm1Xz
Targeted Allele Detail

Summary

• Symbol: Park7^tm1Xz
• Name: Parkinson disease (autosomal recessive, early onset) 7; targeted mutation 1, Xiaoxi Zhuang
• MGI ID: MGI:3586448
• Synonyms: DJ-1^-
• Gene: Park7 Location: Chr4:150981590-150994378 bp, - strand Genetic Position: Chr4, 81.52 cM, cytoband E1
• Alliance: Park7^tm1Xz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99905
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette flanked by FRT sites replaced the first five exons and part of the promoter. RT-PCR confirmed absence of transcript in mutant skin fibroblasts. (J:99905)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Park7 Mutation: 56 strains or lines available

References

• Original: J:99905 Chen L, et al., Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem. 2005 Jun 3;280(22):21418-26
• All: 12 reference(s)