Amd1^tm1Kiga
Targeted Allele Detail

Summary

• Symbol: Amd1^tm1Kiga
• Name: S-adenosylmethionine decarboxylase 1; targeted mutation 1, Kazuei Igarashi
• MGI ID: MGI:3586494
• Synonyms: Amd1^-
• Gene: Amd1 Location: Chr10:40163454-40178184 bp, - strand Genetic Position: Chr10, 21.85 cM, cytoband B2
• Alliance: Amd1^tm1Kiga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99895
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An EGFP-loxP-neo-loxP cDNA was inserted in frame to exon 1, downstream of the ATG. Northern blot and RT-PCR failed to detect transcript in mutant blastocysts. (J:99895)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Amd1 Mutation: 17 strains or lines available

References

• Original: J:99895 Nishimura K, et al., Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development. Genes Cells. 2002 Jan;7(1):41-7
• All: 1 reference(s)