Chrng^tm1Mtak
Targeted Allele Detail

Summary

• Symbol: Chrng^tm1Mtak
• Name: cholinergic receptor, nicotinic, gamma polypeptide; targeted mutation 1, Masazumi Takahashi
• MGI ID: MGI:3586495
• Synonyms: AChRgamma^-
• Gene: Chrng Location: Chr1:87133533-87139365 bp, + strand Genetic Position: Chr1, 44.07 cM
• Alliance: Chrng^tm1Mtak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99894
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo was inserted to replace exon 4. Northern blot of mutants failed to detect the wild-type transcript. However, shorter transcripts thought to result from alternative splicing were present. (J:99894)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Chrng Mutation: 31 strains or lines available

References

• Original: J:99894 Takahashi M, et al., Spontaneous muscle action potentials fail to develop without fetal-type acetylcholine receptors. EMBO Rep. 2002 Jul;3(7):674-81
• All: 2 reference(s)