Fzd9^tm1Sjp
Targeted Allele Detail

Summary

• Symbol: Fzd9^tm1Sjp
• Name: frizzled class receptor 9; targeted mutation 1, Samuel J Pleasure
• MGI ID: MGI:3586504
• Gene: Fzd9 Location: Chr5:135277792-135279901 bp, - strand Genetic Position: Chr5, 75.08 cM
• Alliance: Fzd9^tm1Sjp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99893
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire 1.8 kb coding exon was replaced by an IRES-lacZ-loxP-neo-loxP cassette. RT-PCR of mutant brain confirmed recomibination and expression of lacZ. X-gal staining, however, did not detect lacZ. Immunohistochemistry demonstrated lack of endogenous protein in mutants. (J:99893)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fzd9 Mutation: 37 strains or lines available

References

• Original: J:99893 Zhao C, et al., Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval. Development. 2005 Jun;132(12):2917-27
• All: 2 reference(s)