Igk-J^tm1Mcdl
Targeted Allele Detail

Summary

• Symbol: Igk-J^tm1Mcdl
• Name: immunoglobulin kappa chain, joining region; targeted mutation 1, Maria A Curotto de Lafaille
• MGI ID: MGI:3586522
• Gene: Igk-J Location: unknown Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100072
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• All five heavy chain J elements were replaced with a rearranged V(D)J region. (J:100072)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igk-J Mutation: 11 strains or lines available

References

• Original: J:100072 Curotto de Lafaille MA, et al., Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. J Exp Med. 2001 Nov 5;194(9):1349-59
• All: 7 reference(s)