Upp1^tm1Gp
Targeted Allele Detail

Summary

• Symbol: Upp1^tm1Gp
• Name: uridine phosphorylase 1; targeted mutation 1, Giuseppe Pizzorno
• MGI ID: MGI:3586525
• Synonyms: UPase^-
• Gene: Upp1 Location: Chr11:9068103-9086170 bp, + strand Genetic Position: Chr11, 6.13 cM, cytoband A1-2
• Alliance: Upp1^tm1Gp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99912
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3, all of exon 4 and most of exon 5 were replaced with a neomycin resistance gene. This deletion resulted in the loss of 92 amino acids followed by a frame shift. RT-PCR of mutant liver, gut, lung and kidney confirmed absence of transcript. (J:100071)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Upp1^tm1Gp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Upp1 Mutation: 66 strains or lines available

References

• Original: J:99912 Cao D, et al., Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. J Biol Chem. 2005 Jun 3;280(22):21169-75
• All: 10 reference(s)