Treh^tm1Tkam
Targeted Allele Detail

Summary

• Symbol: Treh^tm1Tkam
• Name: trehalase (brush-border membrane glycoprotein); targeted mutation 1, Takashi Kamiya
• MGI ID: MGI:3586558
• Gene: Treh Location: Chr9:44584530-44597602 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: Treh^tm1Tkam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99998
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5-10 were replaced with a neomycin resistance gene. RT-PCR and Northern blot analyses confirmed recombination in mutants. (J:99998)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Treh Mutation: 27 strains or lines available

References

• Original: J:99998 Kamiya T, Targeted disruption of the trehalase gene: determination of the digestion and absorption of trehalose in trehalase deficient mice. Nutr Res. 2004;24(2):185-96
• All: 2 reference(s)