Tg(Myh6-Tnf)2Brgi
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnf)2Brgi
• Name: transgene insertion 2, Brett Giroir
• MGI ID: MGI:3586567
• Transgene: Tg(Myh6-Tnf)2Brgi Location: unknown
• Alliance: Tg(Myh6-Tnf)2Brgi page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tnf)2Brgi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnf (MGI:104798)

• Mutation details: The tumor necrosis factor alpha gene was placed under the control of the mouse alpha cardiac myosin heavy chain promoter. Six founder mice were produced of which, four produced an abnormal phenotype. Only two of the phenotypically abnormal founders reproduce. Lineage 2 contained approximately 5 copies of the transgene. (J:100006)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100006 Bryant D, et al., Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation. 1998 Apr 14;97(14):1375-81
• All: 2 reference(s)