Thy1^tm1Rjmo
Targeted Allele Detail

Summary

• Symbol: Thy1^tm1Rjmo
• Name: thymus cell antigen 1, theta; targeted mutation 1, R J Morris
• MGI ID: MGI:3586862
• Synonyms: Thy1^-
• Gene: Thy1 Location: Chr9:43954681-43959876 bp, + strand Genetic Position: Chr9, 24.52 cM
• Alliance: Thy1^tm1Rjmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31610
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a neomycin resistance cassette disrupted the codon for the third amino acid of the mature protein, located in the third exon. Immunoblotting and immunohistochemistry were both unable to detect protein in mutants. (J:31610)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Thy1 Mutation: 211 strains or lines available

References

• Original: J:31610 Nosten-Bertrand M, et al., Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1. Nature. 1996 Feb 29;379(6568):826-9
• All: 24 reference(s)