Cks2^tm1Sir
Targeted Allele Detail

Summary

• Symbol: Cks2^tm1Sir
• Name: CDC28 protein kinase regulatory subunit 2; targeted mutation 1, Steven I Reed
• MGI ID: MGI:3586897
• Synonyms: CKS2^-
• Gene: Cks2 Location: Chr13:51799268-51804696 bp, + strand Genetic Position: Chr13, 26.12 cM
• Alliance: Cks2^tm1Sir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99997
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting construct was designed to insert a PGK-neo into exon 1, thereby eliminating 92% of the coding sequence. Western blot confirmed absence of protein in mutant MEFs. (J:99997)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cks2 Mutation: 33 strains or lines available

References

• Original: J:99997 Spruck CH, et al., Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis. Science. 2003 Apr 25;300(5619):647-50
• All: 2 reference(s)