Fem1b^tm1Jfma
Targeted Allele Detail

Summary

• Symbol: Fem1b^tm1Jfma
• Name: fem 1 homolog b; targeted mutation 1, Joseph F Maher
• MGI ID: MGI:3586916
• Synonyms: Fem1b^-
• Gene: Fem1b Location: Chr9:62699106-62718930 bp, - strand Genetic Position: Chr9, 33.87 cM
• Alliance: Fem1b^tm1Jfma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100017
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced the first exon, which contains the translation initiation codon and the first two ankyrin repeats. Northern blot from mutant testis confirmed absence of transcript and Western blot of mutant brain showed absence of protein. (J:100017)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fem1b Mutation: 29 strains or lines available

References

• Original: J:100017 Lu D, et al., Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the fem1b gene. Mol Cell Biol. 2005 Aug;25(15):6570-7
• All: 1 reference(s)