Mbp^tm1Atc
Targeted Allele Detail

Summary

• Symbol: Mbp^tm1Atc
• Name: myelin basic protein; targeted mutation 1, Anthony T Campagnoni
• MGI ID: MGI:3586965
• Synonyms: golli^-
• Gene: Mbp Location: Chr18:82493271-82603762 bp, + strand Genetic Position: Chr18, 55.84 cM, cytoband E2-E4
• Alliance: Mbp^tm1Atc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100022
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo marker in reverse orientation replaced exon 2. Western blot of mutant brain, thymocytes and splenocytes confirmed absence of protein. (J:100022)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbp Mutation: 32 strains or lines available

References

• Original: J:100022 Jacobs EC, et al., Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene. J Neurosci. 2005 Jul 27;25(30):7004-13
• All: 8 reference(s)