Ndn^tm1Ky
Targeted Allele Detail

Summary

• Symbol: Ndn^tm1Ky
• Name: necdin, MAGE family member; targeted mutation 1, Kazuaki Yoshikawa
• MGI ID: MGI:3586988
• Synonyms: Ndn^-
• Gene: Ndn Location: Chr7:61998025-61999676 bp, + strand Genetic Position: Chr7, 34.36 cM, cytoband C
• Alliance: Ndn^tm1Ky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100024
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insetion of a PGK-neo into the coding sequence disrupted the locus. Western blot of mutants showed absence of protein. (J:100024)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ndn Mutation: 18 strains or lines available

References

• Original: J:100024 Kuwako K, et al., Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. J Neurosci. 2005 Jul 27;25(30):7090-9
• All: 12 reference(s)