Isg15^tm1Kpk
Targeted Allele Detail

Summary

• Symbol: Isg15^tm1Kpk
• Name: ISG15 ubiquitin-like modifier; targeted mutation 1, Klaus-Peter Knobeloch
• MGI ID: MGI:3586990
• Synonyms: ISG15^-
• Gene: Isg15 Location: Chr4:156283912-156285253 bp, - strand Genetic Position: Chr4, 88.61 cM
• Alliance: Isg15^tm1Kpk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100028
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed PGK-neo cassette replaced the complete coding region. Northern blot of mutant bone marrow failed to detect transcript. Western blot failed to detect protein in mutants. (J:100028)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Isg15 Mutation: 20 strains or lines available

References

• Original: J:100028 Osiak A, et al., ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus. Mol Cell Biol. 2005 Aug;25(15):6338-45
• All: 31 reference(s)