Ppp1r12a^tm1Mito
Targeted Allele Detail

Summary

• Symbol: Ppp1r12a^tm1Mito
• Name: protein phosphatase 1, regulatory subunit 12A; targeted mutation 1, Masaaki Ito
• MGI ID: MGI:3586994
• Synonyms: MYPT1^-
• Gene: Ppp1r12a Location: Chr10:107997913-108115846 bp, + strand Genetic Position: Chr10, 56.33 cM, cytoband C
• Alliance: Ppp1r12a^tm1Mito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100069
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A neomycin resistance gene was inserted into exon 1, allowing only the first 12 amino acids to be transcribed. The N-terminal fragment was not detected in mutants by either Northern or Western blot analyses. (J:100069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r12a Mutation: 62 strains or lines available

References

• Original: J:100069 Okamoto R, et al., The targeted disruption of the MYPT1 gene results in embryonic lethality. Transgenic Res. 2005 Jun;14(3):337-40
• All: 1 reference(s)